Despite the promising results with NET models and the initiated clinical trials in NET patients and in PCa patients, our current preclinical data strongly urge for further research into PSMA-TRT PCa efficacy by (1) selecting the proper preclinical models to perform the research, (2) evaluating more dedicated and optimized PSMA-TRT and PARPi therapy protocols (for example improved treatments schedules based on pharmacokinetics) and (3) defining biomarkers that could be used to predict efficacy and toxicity. The gene discussed is FOLH1; the disease is posterior cortical atrophy.