Moreover, if confirmed by further data on a larger scale, the possibility of obtaining a reliable characterization of TSR from biopsies might allow us to use the latter as a predictive biological marker also in non-surgical settings, such as in advanced non-resectable cases, in a way similar to the current analysis of PD-L1 on biopsies in advanced head and neck cancers potentially suitable for checkpoint inhibitors [16,38]. This evidence concerns the gene CD274 and head and neck cancer.