According to Western blot results, the expression levels of endogenous α-synuclein and phosphorylated (p)-α-synuclein in the substantia nigra of mice in the 200 ppm group were significantly higher than those in the control group, suggesting that this may be one of the mechanisms through which zinc triggers neurotoxicity and contributes to the pathogenesis of PD. The gene discussed is SNCA; the disease is Parkinson disease.