These different forms of α-synuclein exist in a dynamic equilibrium that is influenced by external (such as pH changes, environmental poisons, and metal ions) and internal factors (such as cytochrome C and apolipoprotein E) that promote or inhibit the fibrosis of α-synuclein, suggesting that altering this balance may be a suitable intervention strategy for PD treatment [24,25,26]. Here, SNCA is linked to Parkinson disease.