EWSR1 and Ewing sarcoma: On the other hand, specific TF–DNA interactions can also initiate and stabilize condensates by organizing chromatin interactions at SE loci, as exemplified by the FET (FUS/EWS/TAF15) family protein EWS, which can form transactivation hubs that target GGAA microsatellites for aberrant oncogene activation and expression associated with Ewing’s sarcoma [104,145].