The researchers evaluated DC subpopulations of NPs from patients with eosinophilic CRSwNP and non-eosinophilic CRSwNP and found that cDC1 isolated from non-eosinophilic NPs could bias naive T cells to Th1 and Th17 phenotypes, but only DCs from eosinophilic NPs could bias naive T cells to Th2 phenotypes [82]. Here, MPPE1 is linked to chronic rhinosinusitis with nasal polyps.