PIAS3 and neoplasm: Additionally, a recent study has shown that the overexpression of the receptor tyrosine kinase-like orphan receptor 2 (ROR2), decreased in PCa patients, would suppress miR-199a-5p levels, increasing PIAS3 expression and consequently downregulating AKT2 and AKT phosphorylation, which leads to the inhibition of tumor cell migration and invasion [192].