In the human GC cell line SCG7901, a study carried out under inflammatory conditions with IL-6, a cytokine that is secreted by cancer cells, has shown that overexpression of PIAS1 decreases the migratory and invasive capacity produced by IL-6 treatment in these cells, preventing transcriptional activation of the PI3K/AKT signaling pathway. The gene discussed is AKT1; the disease is cancer.