BDNF and juvenile Huntington disease: For example, research conducted by Suelves and colleagues [62] examined the consequences of BDNF/TrkB/p75NTR imbalance in a Huntington’s disease (HD) mouse model, showing that the reduction of BDNF and TrkB levels, along with an increase in p75NTR expression, correlated with striatal neuropathology and motor dysfunction.