Considering the key role of IGF-1R in the ovary [58,59], it is possible that a similar mechanism may partially explain the adverse reproductive outcomes such as an increased risk of infertility due to ovulatory abnormalities [74], fewer and poorer quality oocytes and lower pregnancy rates by in vitro fertilization (IVF) [75] that have been reported in adult cannabis users. The gene discussed is IGF1R; the disease is Infertility.