Although cumulative evidence reveals that DAPK1 plays crucial roles in AD development and that hsa-miR-143-3p is a promising noninvasive biomarker for AD diagnosis, little is known regarding whether and how hsa-miR-143-3p is implicated in AD pathogenesis, and the molecular link between DAPK1 and hsa-miR-143-3p remains unclear. Here, DAPK1 is linked to Alzheimer disease.