Some other critical AD-related proteins, including presenilin 2 (PSEN2), beta-site APP cleaving enzyme-1 (BACE1), a disintegrin and metalloproteinase 10 (ADAM10), and a disintegrin and metalloproteinase 17 (ADAM17), might not be directly modulated by DAPK1. Here, PSEN2 is linked to Alzheimer disease.