Indeed, it has been reported that oxidative stress increases the level of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and IL-6 and also upregulates nuclear factor-kappa B (NF-κB), leading to an increase of the inflammatory state responsible for the onset of several inflammatory and autoimmune diseases [21,22] (Figure 2). The gene discussed is TNF; the disease is autoimmune disease.