Interestingly, Özdemir and colleagues recently showed that primary and bone metastatic PCa displayed strong periostin immunoreactivity in myofibroblasts over the entire tumor stroma, while cancer cells were negative [14].However, the role of stromal periostin and the contribution of its deregulated expression in PCa has not yet been fully elucidated. Here, POSTN is linked to posterior cortical atrophy.