By analyzing the gene expression profile of patient-derived prostate CAFs and normal prostate fibroblasts (NPFs) activated in vitro with IL-6 or TGF-β (data from Doldi et al. [8], deposited at GEO DataSets as GSE76260), we identified a panel of ECM genes (POSTN, SPARC, COMP, COL11A1, and COL10A1) up-modulated in at least one type of reactive samples (CAFs or in vitro activated fibroblasts) compared to NPFs, suggesting that the composition of ECM in the peritumoral stroma of PCa may be distinct from that of normal tissue. This evidence concerns the gene SPARC and posterior cortical atrophy.