In this context, we have previously found that CAF activation in PCa is guided by pivotal cancer-derived factors, such as Transforming Growth Factor β (TGF-β) and Interleukin 6 (IL-6), which can both act by creating an inflammatory and hypoxic stroma microenvironment suitable for tumor progression and spreading [6,7,8]. Here, TGFB1 is linked to posterior cortical atrophy.