SHBG and cancer: Top downregulated proteins included Amyloid-like protein 1, Desmoglein-2, SHBG, secretogranin-3 (SCG3), and vesicular, overexpressed in cancer, prosurvival protein 1 (ECOP), with pathways like those listed for proteins negatively associated with AHI, plus fibrinolysis pathways, complement system pathways, and others (Supplementary Table S6C).