We further trained a similar machine learning classifier as previously described with the 5 proteins significant for AHI in the STAGES cohort, combined cohort, and that were responsive to CPAP (i.e., CRP, PAI-I, TrATPase, tPA, and sE-Selectin) for classifying participants into OSA or control categories based on an AHI cutoff score of 15. The gene discussed is PLAT; the disease is obstructive sleep apnea syndrome.