Of the 42 significant predictive features of the OSA machine learning classifier, 8 of the top 15 features were significant markers of total AHI and OSA from multivariate analysis, suggesting that these 8 proteins (Amyloid-like protein 1, tPA, PAI-1, CRIP1, SCG3, ECOP, Desmoglein-2, and SHBG) are likely predictors of the presence and severity of sleep apnea. This evidence concerns the gene DSG2 and sleep apnea syndrome.