Of the top 15 classifier features from Model 1 (Supplementary Table S10), 10 proteins were identified as significant protein markers of AHI, and 8 were significant DEPs for moderate-to-severe OSA (Amyloid-like protein 1, tPA, PAI-1, CRIP1, SCG3, ECOP, Desmoglein-2, and SHBG), suggesting these proteins are robust predictors of the presence and severity of sleep apnea. The gene discussed is SHBG; the disease is sleep apnea syndrome.