GPX4 and acute myeloid leukemia: A biochemical analysis of CRISPR-modified AML cells by Jiang and co-workers suggested that the deficiency to produce antioxidants, such as GPX1 and GPX4, disrupted the redox environment necessary for the viability of AML cells, as evidenced by the reduced antioxidant Gpx4 and increased DNA damage marker γ-H2AX protein expression levels [168].