The CRISPR deletion of genes critical to the synthesis of selenoproteins, such as SEPHS2, SEPSECS, and EEFSEC in human AML cells (e.g., MOLM-13, Kasumi-1, THP-1, and patient-derived xenograft samples) and murine AML cells with an MLL-AF9 mutation exhibited a reduced proliferation and an enhanced production of ROS relative to healthy cord blood and myeloma cells (U266B1) [168]. Here, MLLT3 is linked to acute myeloid leukemia.