These genes were found to have key roles in cancer survival (e.g., TXNRD1 and TXNRD3 are correlated with a poor prognosis), the tumor microenvironment (e.g., TXNRD1, GPX1, and GPX2 are linked to tumor mutagenesis and development), and drug sensitivity (TXNRD1, GPX1, GPX2, and GPX3 are associated with the formation of drug resistance) [26]. The gene discussed is TXNRD3; the disease is neoplasm.