A further example of interesting hmsLRI-E overlapping microdeletions is represented by two intronic enhancers of ZEB2 (i.e., hmsLRI-E wTR1_3899, including wTR1_3900, Figure 6C), a gene whose mutations cause Mowat–Wilson Syndrome, characterized by intellectual disability and microcephaly [47] and recently implicated in human-specific neurodevelopmental processes [48]. This evidence concerns the gene ZEB2 and microcephaly.