In another study, treatment of high-fat-diet/streptozotocin-induced type 2 diabetic Sprague-Dawley male rats with superparamagnetic iron oxide NPs at 22, 44, and 66 μmol Fe/kg body-weight once a week for four weeks normalized their fasting blood glucose level, lowered their insulin level, and corrected their blood lipid profile [275]. The gene discussed is INS; the disease is type 2 diabetes mellitus.