Zinc oxide NPs have been found to have positive effects and to help normalize iNOS expression and ●NO production in several disease models such as inflammation with LPS-induced RAW 264.7 cells [326], diabetes with streptozotocin-induced diabetic male albino rats [287], and bacterial infection with nontypeable Haemophilus influenzae infected RAW 264.7 cells and C57BL/6 mice [327]. This evidence concerns the gene NOS2 and diabetes mellitus.