NLRP3 inflammasome is a key component of the innate immune system, and abnormal activation of the NLRP3 inflammasome has been implicated in various inflammatory diseases, including Alzheimer’s disease, diabetes, atherosclerosis, acute pancreatitis, fibromyalgia, etc. [24,25,26,27,28,29]. Here, NLRP3 is linked to fibromyalgia.