The high level of Trop-2 potentially contributes to extracellular regulated protein kinase (ERK) 1/2 phosphorylation, followed by the upregulation of the downstream transcription factor apoptotic protease activating factor-1 (AP-1), which is a target of many tumor-associated genes, such as apoptosis- (B-cell lymphoma-2 (BCL-2), FasL), invasion-, and metastasis-related (matrix metalloproteinases (MMPs), Bordopram, Ezrin) genes. The gene discussed is TACSTD2; the disease is neoplasm.