In addition, MCF-7 breast cancer cells accumulated in the G1 phase upon the KD of TRPC1 [12], which was also found in the thyroid cancer cell line ML-1, where the expression of the CDK6, Cyclin D2, and D3 decreased, and the expression of their regulating inhibitor p21 increased [24]. The gene discussed is CCND2; the disease is breast carcinoma.