LPAR2 and serum lipopolysaccharide activity: Lpar2 genetic deletion, on the other hand, did not seem to have an impact on survival upon LPS-induced endotoxemia (Figure 4B. Moreover, the pharmacologic inhibition of LPAR5 with AS2717638 has been recently reported to attenuate IP LPS-induced serum cytokine levels as well as inflammatory markers in the mouse brain [30].