Although studies have investigated the p53-related mechanism of mortalin for the treatment of cancer [42,43,44,45], research on the underlying mechanism of mortalin on pathologic scars (keloid or hypertrophic scar) [13] or on other functions, such as chaperonization and intracellular trafficking via association with the IL-1 receptor, is limited. The gene discussed is TP53; the disease is cancer.