The decrease in AchE activity leads to elevate Ach levels in NSCLC cells, which could promote cell proliferation, migration, invasion, angiogenesis, and reduce apoptosis/autophagy through activating Ca2+ channels, TGF-β-induced EMT and α7nAChR-mediated signaling pathways such as PI3K/Akt, ERK/MAPK, GSK-3β, and STAT3 [97]. Here, CHRNA7 is linked to non-small cell lung carcinoma.