TP53 and non-small cell lung carcinoma: Inactivation of p53 was found to increase Aβ40 and Aβ42 levels in A549 cells via upregulation of the PI3K/Akt/NFκB signaling pathway and MMP2/9 expression, known to increase viability and reduce apoptosis in NSCLC cells, suggesting that activation of p53 may be helpful in reducing the levels of Aβ40 and Aβ42 responsible for viability and anti-apoptosis in NSCLC cells [93].