CHRNA7 and non-small cell lung carcinoma: In addition, natural flavonoids present in fruits (e.g., citrus) in combination with chemotherapeutic agents, such as cisplatin, have shown anti-NSCLC effects, demonstrated by inhibition of the α7nAChR-mediated signaling pathways involved in cellular processes including proliferation, inflammation and anti-apoptosis [13,16].The health benefits of fruits are due to the high levels of bioactive flavonoids they contain, such as PCs and ACNs [17,18].