CHRNA7 and non-small cell lung carcinoma: Taken together, nicotine-mediated activation of cell proliferation, migration, invasion, angiogenesis, and inhibition of apoptosis in NSCLC cells can be modulated when PCs and ACNs interact with the active site of α7AChR, displaying complex modulation of several transcription/growth factors via signaling pathways involved in α7nAChR activation, suggesting that such compounds may have a significant role in the treatment of NSCLC (Figure 2).