HSPG2 and neoplasm: We observed that in the tumor matrix, the expression of HSPG2 was increased in M2 macrophages co-assembled with MDA-MB-231 cells compared to M2 + MCF7 cells (1.72- vs. 0.34-fold, p = 0.0008), correlated with the deposition of HSPG2 by CD206+ macrophages in TNBC biopsies (Figure 1c).