In case of hypoxia, hypoxia-inducible factors (HIFs) activate the transcription of numerous target genes that mediate both adaptive and maladaptive responses, including erythropoiesis, angiogenesis, metabolic reprogramming, or cardiovascular disease [1], while hyperoxia involves the production of ROS, which initiate signaling via the modulation of many molecules, such as NF-E2, Nrf2, or NF-kB [63]. The gene discussed is NFE2; the disease is cardiovascular disorder.