Apart from PD-1, other T-cell exhaustion markers are also targets for ICI and are upregulated in HPV-positive HNSCC, such as cytotoxic T-lymphocyte protein 4 (CTLA4), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and lymphocyte activation gene 3 protein (LAG3) [183,184]. Here, LAG3 is linked to head and neck squamous cell carcinoma.