STAT3 and cancer: In addition to its direct effects on cancer cells, STAT3 also contributes to tumor vascularization and cancer immune evasion [134] by inhibiting the maturation of dendritic cells [135,136,137,138] and stimulating immunosuppressive cells in the tumor microenvironment, including myeloid-derived suppressor cells [139,140,141], M2 macrophages [135,142,143], T-helper 17 cells [144,145,146], and regulatory T cells [135].