In addition to apoptosis and autophagy induced by RPIA knockdown, we also observed that the knockdown of RPIA in A549 lung cancer cells resulted in a broad and flattened cellular phenotype similar to senescence (Figure 7a), and exhibited increased senescent cells with enhanced senescence-associated β-galactosidase (SA β-gal) activity (Figure 7b). Here, RPIA is linked to lung cancer.