Since the knowledge of the chemokine receptor expression profiles in de novo and transformed DLBCL is limited, we examined the mRNA expression levels of 18 well-characterized chemokine receptors in primary lymphoma tissue samples, consisting of GCB-DLBCL (n = 8) and NGCB-DLBCL (n = 18), one unclassified de novo DLBCL, tFL (n = 16), and RS (n = 14), as well as GC-B (n = 4) serving as the non-neoplastic controls. The gene discussed is GC; the disease is diffuse large B-cell lymphoma.