AURKA and acute megakaryoblastic leukemia: Back in 2012, Wen Q.J. et al. identified a panel of small molecules which induced MK polyploidization, differentiation and subsequent apoptosis in acute megakaryocytic leukemia (AMKL); among those, MLN8237 (Alisertib), a selective inhibitor of Aurora A kinase (AURKA), proved capable of making AMKL blasts express mature MK markers and displayed potent anti-AMKL activity in vivo [42].