Importantly, our data show that colorectal cancer cells are sensitive to HMGB1 independently of their genetic (MSI/MSS, BRAF WT/BRAF mutated, KRAS WT/KRAS mutated and TP53 WT/TP53 mutated) and phenotypic (epithelial/mesenchymal) status. Here, BRAF is linked to colorectal cancer.