Treatment of T2DM model ZDF (Zucker diabetic fatty) rats with zinc and acetylsalicylic acid (as bis(aspirinato)zinc(II)-complex Zn(ASA)2) resulted in normalisation of left-ventricular diastolic stiffness, collagen content, reduction of cardiomyocyte DNA-fragmentation, and nitro-oxidative stress, presumably, acting via upregulation of AKT (Protein Kinase B), a crucial regulator of many cellular functions (such as cell proliferation, metabolism, survival, angiogenesis, and others) [75,76]. This evidence concerns the gene AKT1 and type 2 diabetes mellitus.