Mice lacking key inflammasome components, such as caspase 1 or caspase 11 (Ice−/− or Nlrp3 (Nlrp3−/− ), have exacerbated CLM after MC38 intrasplenic injection, which supports the requirement of this pathway to suppress CRC growth in this organ [171]. The gene discussed is CASP1; the disease is colorectal carcinoma.