A similar phenomenon mediated by another CYP450 family member, CYP1A2, has been observed in hepatocellular carcinoma, in which CYP1A2 catalyzes metabolic transformation from 17β-estradiol to 2-methoxyestradiol, thus markedly inhibiting proliferation and triggering apoptosis [36]. The gene discussed is CYP1A2; the disease is hepatocellular carcinoma.