The expression of the polyductin in DPM of the intrahepatic biliary tree and in liver biopsies of patients with neonatal cholestasis, mostly BA, as well as in congenital hepatic fibrosis [4] and its re-expression during BA with DPM, underlines that polyductin expression should be studied in BA animal models. This evidence concerns the gene PKHD1 and breast angiosarcoma.