In response to DNA damage, the p38/MK2 complex is relocated from the nucleus to the cytoplasm where MK2 phosphorylates hnRNPA0 to stabilize GADD45alpha mRNA, while p38 phosphorylates and releases TIAR, suggesting a role for the MK2 pathway in the post-transcriptional regulation of gene expression as part of the DNA damage response in cancer cells [65]. Here, TIAL1 is linked to cancer.