Recently, many studies highlighted a role for a complex TYR genotype in determining a mild form of oculocutaneous albinism: a double-polymorphism haplotype, p.[Ser192Tyr;Arg402Gln], existing on the trans allele to a pathogenic TYR variant [5,7,8,9,10]. The gene discussed is TYR; the disease is oculocutaneous albinism.