Two precursor lesions for HDGC have been described in CDH1-carriers—first, “in situ signet-ring cell carcinoma” (SRCC), which is characterized by signet-ring cells (SRC) with hyperchromatic and depolarized nuclei located in glandular basal membranes; second, rows of SRCs with pagetoid growth patterns inside the glandular basal membrane and below the non-neoplastic glandular epithelium and foveola. The gene discussed is CDH1; the disease is Familial gastric cancer.