PERK phosphorylation has been observed in post-mortem brain tissue from patients with frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), AD, and PD [74], and is thought to play a key role in a wide range of neurodegenerative disorders, besides ALS (reviewed in Hetz and Saxena, 2017 [74]). This evidence concerns the gene EIF2AK3 and amyotrophic lateral sclerosis.