Consistent with this observation, Volkmer et al. [35] and Ho et al. [105] demonstrated that CK14 defined the most primitive/least differentiated basal-type urothelial carcinoma, which preceded the emergence of cancer cells expressing CK5 (intermediately differentiated) or CK20 (well-differentiated); further, CK14 expression marked the highly tumorigenic stem cell population. This evidence concerns the gene KRT14 and cancer.