Key SLC transporters such as glucose transporter 1, GLUT-1 (SLC2A1), large neutral amino acid transporter 1, LAT-1 (SLC7A5) and monocarboxylate transporter 1, MCT1 (SLC16A1) showed comparable functional activity in the healthy and in the HD models. This evidence concerns the gene SLC16A1 and Huntington disease.