Phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)-pyrrolidin-3-yl)carbamate 1 (PDDC), an nSMase2 inhibitor, was reported to have significant improvement cognition in 5XFAD mice, a mouse model of AD. Here, SMPD3 is linked to Alzheimer disease.