In view of the apparent homogeneous hypomethylation of FBXL7, we verified its discriminatory potential, regarding the CpG relative to the cg11339964 probe, between the NTST and tumor by applying a receiver-operating characteristics (ROC) curve analysis, showing accuracies of 88.1%, 85.2% and 94.4% for ESCC, LSCC and OCSCC, respectively (Figure 1E). Here, FBXL7 is linked to neoplasm.