Esophageal adenocarcinoma (EAC) cases showed FBXL7 hypomethylation relative to the non-tumor esophageal mucosa (p < 0.0001), Barrett’s esophagus (p = 0.0319) and esophageal mucosa from individuals with gastroesophageal reflux disease (GERD, p < 0.0001) (Figure 2A). The gene discussed is FBXL7; the disease is gastroesophageal reflux disease.