HSPD1 and ductal breast carcinoma in situ: The presence of autoantibodies against Hsp60 was reported in 31 and 32.6% of early BC sera and DCIS, respectively, compared to 4.3% in healthy controls, suggesting that chaperonin plays a role in early carcinogenesis, and, therefore, Hsp60 may be considered of interest in the development of immunotherapeutic approaches [155].