Let-7 family members also targeted and downregulated the IR/IGF pathway in PDAC; miR-7 is a brain-abundant miRNA that targets the IR, IRS-2, and insulin-degrading enzyme (IDE), and thus affects insulin signaling through posttranscriptional regulation of the IRS-2, IR, and IDE pathways in AD patients [258]. The gene discussed is IDE; the disease is Alzheimer disease.