BACE1 and Alzheimer disease: In brain tissues of AD mice, the down-regulated miR-200c can exacerbate tau protein phosphorylation in brain tissues and reduce learning and memory capacity of the mice [66]; the elevated miR-34c can reduce synaptic plasticity [67], the reversal of miR-29c-3p can suppress the targeting of BACE1 to activate the Wnt/β-catenin signaling pathway [68], and the elevation of miR-155 can induce neuroinflammation and cognitive impairment [69,70].