As an α2-adrenoceptor agonist, Dexmedetomidine is often used as a sedative, as shown in rescuing the impaired learning and memory capacity of AD mice through suppressing miR-129-mediated neuronal apoptosis through yes-associated protein 1/Jagged-1 (YAP1/JAG1) axis [95]. This evidence concerns the gene JAG1 and Alzheimer disease.