Distinct populations of CSCs in hepatocellular carcinoma (HCC) have been defined and characterized using normal liver stem cell markers and liver progenitor cell markers, including CD44, CD133/PROM-1, CD90/THY-1, aldehyde dehydrogenase, CD13, oval cell marker OV-6, Sal-like protein 4, CD117/c-kit, intercellular adhesion molecule 1, CD24, delta-like 1, cytokeratin 19, and epithelial cell adhesion molecule (EpCAM) [3,4]. This evidence concerns the gene PROM1 and hepatocellular carcinoma.