The serine protease inhibitor SERPINA1 was highly expressed in endometrial cancer specimens from Asian (mean 483.88 ± 609.04 vs. 57.05 ± 52.81 RU, p = 0.011) and American Indian races (mean 306.92 ± 219.87 vs. 57.05 ± 52.81 RU, p = 0.009). The gene discussed is SERPINA1; the disease is endometrial cancer.