Of the 157 genes, 27 were included in the eight pathways described above: 18 genes (IL1B, SUCNR1, MUC1, PLXNB1, IFNB1, OR1L4, MUC16, OR1Q1, GRM1, OR1L8, RAMP1, IFNW1, OR1J1, IL5RA, OR13C4, GDF6, GNG8 and RTP3) were upregulated while nine genes (OR5B12, CLEC10A, CCR5, PDGFA, WNT10A, DAGLA, TNFSF15, TNFRSF11A, and CSF1R) were downregulated in the PD-AML group, compared with the PND-AML group (Figure 1). The gene discussed is GDF6; the disease is acute myeloid leukemia.