EIF2AK3 and pulmonary emphysema: The phytocompound inhibited the activation of PERK, leading to the down-regulation of Bax pro-apoptotic protein and up-regulation of Bcl-2 anti-apoptotic protein; furthermore, UA was able to inhibit the inflammatory caspase 3 and caspase 9, and stimulate the expression of the Nrf2/ARE pathway, thus alleviating experimental emphysema [257].