ZEB1 is a transcriptional factor in the epithelial-to-mesenchymal transition (EMT), being in a reciprocal feedback loop with miR-200a/b/c, and influencing cellular plasticity; the overexpression of ZEB1 or TGF-β1 stimulates EMT in cancer cells, leading to tumor progression [218]. The gene discussed is TGFB1; the disease is cancer.