AKT1 and hepatocellular carcinoma: Kim et al. highlighted the apoptotic effect of UA against HCC through the modulation of cholesterol supplementation; at low intracellular cholesterol levels, SREBP2 initiates a transcriptional programming through the activation of target genes, inducing de novo cholesterol synthesis, which promotes growth signaling factors such as PI3K/AKT and EGRF/MAPK.