Mu et al. demonstrated the apoptotic effect of UA in vitro on LNCaP human prostate cancer cells; UA modulated the Rho-associated protein kinase 1 (ROCK1)/phosphate and tension homolog (PTEN)- cofilin-1/cytochrome c signaling pathway (Figure 14), leading to the activation of caspase cascade and inducing apoptosis in LNCaP cells. The gene discussed is ROCK1; the disease is Familial prostate cancer.