The same MCF-7 breast cancer cell line was used to reveal the UA modulating activity on the PLK1, IKK/NF-kB, and BRAF/ERK pathways; UA induced MCF-7 cells apoptosis by suppressing the phosphorylation of BRAF, ERK1, and PLK1 levels. This evidence concerns the gene NFKB1 and breast carcinoma.