UA down-regulated the expression of key mediators in the TGF-β1 pathway including TGF-β1, p-Smad2/3, and ZEB1, leading to a decrease in N-cadherin protein expression; it significantly up-regulated miR200a/b/c and subsequently induced apoptosis in colon cancer cell lines [218]. Here, TGFB1 is linked to colonic neoplasm.