AKT1 and malignant colon neoplasm: AA inhibited the proliferation and migration of colon cancer cells in a time- and dose-dependent manner [62] by delaying G2/M and S phase progression; the results indicated the down-regulation of several phosphorylated proteins such as PI3K, Akt, mTOR, and ribosomal protein S6 kinase as well as the up-regulation of the Pdcd4 expression.