Kim et al. have explored the alleviating effect of UA in rheumatoid arthritis in RASF (Rheumatoid arthritis synovial fibroblast); UA facilitated RASF apoptosis by down-regulating the expression of myeloid cell leukemia-1 (Mcl-1) through the enhancement of Noxa selective binding to Mcl-1. The gene discussed is PMAIP1; the disease is rheumatoid arthritis.