Dai et al. analyzed the antioxidant effect of UA in pregnant rats with pre-induced streptozotocin gestational diabetes; the underlying molecular mechanism resides in the modulation of AGEs-RAGE signaling pathway [238], which has been thoroughly studied in several pathologies, particularly in diabetes where it increases oxidative stress by activating pro-inflammatory mediators such as NOX -1, TGF-β, NFkB, and ERK1/2 and down-regulating the SOD-1 expression [239]. Here, NFKB1 is linked to diabetes mellitus.