TRPML2-positive but TRPML1-negative, and TRPML1- and TRPML2-positive cell populations were also evident in T24 and 5637 bladder cancer and BT549 and SKBR3 breast cancer cell lines, whereas TRPML1- and TRPML2-positive, and TRPML1-positive but TRPML2-negative cells were evident in normal human peripheral blood mononuclear cells (PBMCs) used as positive control. The gene discussed is MCOLN2; the disease is urinary bladder carcinoma.