In addition to TrkB full-length (for Akt-, PLCγ-, and ERK-signaling pathways), the truncated isoform TrkB.T1 elicits intracellular signaling independently, and is involved in the pathogenesis of neurological disorders, including AD, Parkinson’s disease, stroke, mood disorders, and schizophrenia (see the review by Tessarollo and Yanpallewar, 2022 [13]). The gene discussed is NTRK2; the disease is mood disorder.