Although it is assumed that ‘Ready-Steady-Go’ in AD involves a stochastic folding of a nontoxic Aβ peptide into a toxic one, which in turn triggers downstream a stochastic folding of the tau protein, it is not to be underestimated that the cellular environment, in which all this takes place, is not alien to what is going on. The gene discussed is MAPT; the disease is Alzheimer disease.