VDAC1 and Alzheimer disease: Dated research [101] revealed that in cortical tissues of APP transgenic mice, the protein levels of VDAC1 were significantly increased in 12- and 24-month-old mice compared with 6-month-old mice, indicating that an age-dependent increase of VDAC1 occurred in the cerebral cortex of these AD mice in a similar manner of affected postmortem brains.